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KMID : 0363420060200010093
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Journal of Korean Oriental Pediatrics
2006 Volume.20 No. 1 p.93 ~ p.107
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Effects of Sigoungcheongpyetang and Tonggyutanggamibang on airway mucus secretion and trecheal smooth muscle contractility
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Han Jae-Kyung
Kim Yun-Hee
Yoon Jae-Eun
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Abstract
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Objective: To investigate the effectiveness of two oriental medical prescriptions named Sigoungcheongpyetang(SCPT) and Tonggyutanggamibang(TGT) for mucin release from cultured hamster tracheal surface epithelial(HTSE) cells.
Method: Confluent HTSE cells were metabolically radiolabeled with $^{3}H-glucosamine$ for 24hrs and chased for 30 min in the presence of SCPT or TGT to assess the effect of each agent $^{3}H-mucin$ release. Possible cytotoxicities of each agent were assessed by measuring lactate dehy drogenase(LDH) release. Also, the effects of SCPT and TGT on contrectility of isolated tracheal smooth muscle were investigated.
Results: (1) SCPT and TGT significantly increased mucin release from cultured HTSE cells, with significantly cytotoxicity ; SCPT did not affect contractility of isolated tracheal smooth muscle and TGT inhibited Ach-induced contraction of isolated tracheal smooth muscle.
Conclusion: We suggest that the effects of SCPT and TGT with their components should be further investigated and it is of great value to find, from oriental medical prescriptions, novel agents which might regulate mucin secretion from airway goblet cells.
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KEYWORD
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airway, mucux, mucin, sigoungcheongpyetang and tonggyu tanggamibang
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